News (Updated April 19, 2009)

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Drug-resistant TB rampant in China and ex-USSR

Wed Apr 15, 7:15 PM

A nurse attends to patients at a way-house for homeless people ...PARIS (AFP) - Multi-drug resistant tuberculosis (MDR-TB) has reached "epidemic" levels in many ex-Soviet nations, and is widespread in several provinces of China , according a new global assessment released Thursday.

Data on more than 90,000 patients in 83 countries covering the period 2002-2007 showed that one-in-nine of the approximately nine million new cases of tuberculosis each year failed to respond to at least one anti-TB drug.

The rates of MDR-TB -- defined as resistant to at least two frontline medications -- were between seven and 22 percent in nine countries from the former Soviet Union, including 19 percent in Moldova and 22 percent in Baku, Azerbaijan.

Overall, nearly a fifth of all TB cases in Eastern Europe were drug resistant.

"The countries of the former Soviet Union are facing a serious and widespread epidemic with the highest prevalence of MDR-TB ever reported in 13 years of global data collection," the study concluded.

In most rich nations, including France , Britain , the Netherlands and New Zealand , the prevalence of drug resistant TB was one percent or lower.

All told, more than half-a-million cases of MDR-TB have emerged since 2006, according to the study, published in the British medical journal The Lancet. Half of them were in China and India .

The most common types of TB can be easily cured with ten euros (14 dollars) worth of medicine if diagnosed early.

But new strains that have built up immunity to standard antibiotics -- especially isoniazid and rifampicin -- can require drug treatments costing thousands of dollars (euros) and lasting a year to 18 months.

And even when properly treated, MDR-TB patients still face a significantly increased risk of death.

The study also found that virulent strain infection rates had increased in many countries since the mid-1990s, when the Global Project on Anti-Tuberculosis Drug Resistance was launched.

Between 1994 and 2007, prevalence jumped from 1.6 to 2.7 percent of all TB cases in South Korea . The percentage of MDR-TB more than doubled in six years -- from 6.5 to 15 percent -- in the Tomsk Oblast region of Russia , and nearly quadrupled between 2002 and 2006 to 8.8 percent in Orel Oblast, also in Russia .

Rates in the Baltic nations of Estonia and Latvia held steady over the course of a decade at 11.3 percent and 10.8 percent, and declined over the same period in Hong Kong and the United States to about one percent.

An even more deadly and virtually untreatable form of the disease, called extensively drug-resistant (XDR) tuberculosis, showed up in 37 nations, with more than 25 cases reported in five former Soviet states: Azerbaijan , Estonia , Latvia , Lithuania and Russian Federation ( Tomsk ).

"Currently, the world is far behind reaching targets for MDR-TB diagnosis and management," the study warned.

The World Health Organisation (WHO) said last month that progress in tackling tuberculosis was far too slow, doubling its estimate of the ravages the disease is causing among HIV/AIDS patients.

Some 9.27 million people contracted TB in 2007, an increase of about 30,000 over the previous year mainly in line with population growth.

They included some 1.4 million people with HIV/AIDS, compared to an estimated 600,000 in 2006.

More than one death in four -- 456,000 of the 1.75 million tuberculosis deaths recorded in 2007 -- is now thought to involve an HIV/AIDS patient.

 

Global effort aims to slash malaria drug costs

Fri Apr 17, 2:56 PM

A community medicine distributor writes the names of malaria ...OSLO (AFP) - More effective drugs to treat malaria are set to be cheaper for Africans to buy at their local pharmacies, under an international partnership launched Friday at a meeting in Norway .

The Affordable Medicines Facility for Malaria aims to push down the cost of modern malaria drugs in order to drive older, ineffective medications off the market, the Global Fund to Fight AIDS, Tuberculosis and Malaria said.

"The age when the world had effective drugs against infectious diseases but let millions die each year because they couldn't afford them is over," said Norwegian Foreign Minister Jonas Gahr Stoere in a statement.

The facility will initially be offered to 10 nations in Africa -- Benin , Ghana , Kenya , Madagascar , Niger , Nigeria , Rwanda , Senegal , Tanzania and Uganda -- as well as Cambodia .

Sharing the initial cost of 225 million dollars (172 million euros) over two years will be Britain and UNITAID, an international drug-buying facility created by France and supported by 27 other nations.

The Global Fund will manage the facility.

Spread by mosquitos in tropical regions, and most notably in poorer developing countries, malaria strikes about 250 million people a year -- one million of whom die, 90 percent of them children.

New drugs, known as artemisinin combination therapies, or ACTs, are available for free in public health clinics, the Global Fund said.

But because they are up to 40 times more expensive over the counter, many malaria sufferers opt for cheaper, older medicines that the malaria parasite has, over time, grown resistant to.

Unitaid said the current price of ACT treatment ranges from six to 10 dollars and would eventually fall to around 20 cents.

"There is no reason any child should die of malaria anymore," said Michel Kazatchkine, executive director of the Global Fund.

"We have insecticide-impregnated bed nets to protect families from mosquitos and effective drugs to treat those who do fall ill. Now we only need to ensure that all who need these things get them."

Unitaid president Philippe Douste-Blazy called for an end to what he called the paradox of an African child dying every 30 seconds from malaria when effective medication exists to counter the illness.

Reversing the incidence of malaria and HIV-AIDS is among the Millenium Development Goals set out by the United Nations in 2000 which notably aim to reduce extreme poverty by half by 2015.

 

Fight against syphilis, AIDS goes online

By LISA CORNWELL, Associated Press Writer Lisa Cornwell, Associated Press Writer Sat Apr 18, 12:58 pm ET

CINCINNATI – As life moves to the Internet, a growing number of public health agencies are signing on to social networking sites — not to find friends but to fight syphilis, AIDS and other sexually transmitted diseases.

Public agencies in Ohio are among the latest to open accounts on online meeting sites in an effort to reach people who may have a sexually transmitted disease and need medical care.

Cleveland 's health department opened accounts on two sites this week, and Cincinnati has plans to start an online effort in a couple of months. Columbus Public Health established a presence a year ago on Manhunt, a social networking site for gay men, and has since added other popular sites.

Debra Mullen, who handles online notifications for Columbus Public Health, contacted a man a year ago who did not know he had syphilis. She heard from him again this week.

"He got treatment and now is asking whether he needs any follow-up," she said.

Traditionally, health departments have used letters and telephone calls to set up preferred face-to-face meetings with the partners of infected people who visit their clinics, test positive for a sexually transmitted disease, and reveal their partners' names to health officials.

But with the Net, the encounters may occur between people who know only each other's online names. Even with that small piece of information, health officials can go to the site, send a message to someone's partner, and advise him or her to contact health officials and provide contact information.

Daniel Pohl of Howard Brown Health Center in Chicago recalls two instances where online notification has done more good than expected.

"One client I was in contact with over a couple of months was an escort. I was able to get him to come in for syphilis testing, and he was infected," said Pohl, the center's manager of disease intervention services. "He was treated for that, but was too afraid to get tested then for HIV."

Over time, the man agreed and tested positive for HIV a year or so ago when he was 19, Pohl said. "He not only became very involved with his own care, but also got involved with a program that helps other young people with HIV."

Pohl said another man who lived with an emotionally abusive male partner was notified and tested negative for HIV and syphilis, but agreed to see a counselor in the center's domestic violence program.

"Sometimes the person on the other end of the e-mail may be completely isolated from support services, and this may help them in many ways," Pohl said.

The National Coalition of STD Directors, consulting with the Centers for Disease Control and Prevention, developed guidelines in 2007 to help public health departments create profiles for confidential online notification. Health officials say the notification cost is minimal — a few thousand dollars for a computer and DSL line dedicated to the program.

Rachel Kachur, a researcher with the CDC's STD prevention division, said she is encouraged more health departments are moving to online notification, but the work is not happening fast enough.

"The national guidelines help by giving local areas a jumping off point where they can tweak them to fit their needs," she said. "But the goal is to get everyone doing this."

Health departments in San Francisco , Washington , D.C., and Massachusetts were among the first to begin using social networks to reach a possibly infected person. The Web sites typically used cater to gays and bisexuals, such as Manhunt and Adam4Adam, but some officials hope to eventually reach the heterosexual population as well.

Cleveland , which has seen a rise in syphilis, started a presence on Manhunt and Adam4Adam this week, said David Merriman, project coordinator overseeing HIV/AIDS services for the city.

"Our goal is to also be on sites like Facebook where we could reach broader populations, including heterosexual adults and adolescents who wouldn't use sites like Manhunt," Merriman said.

In Massachusetts , the state health department has reported a good response since initiating partner notification on Manhunt in 2006. Kevin Cranston, director of the department's infectious diseases bureau, says well over 50 percent of those the agency contacted online responded, with some getting department-documented medical evaluation and treatment and others saying they would seek medical evaluation on their own.

 

VA: 3 patients HIV-positive after clinic mistakes

By BILL POOVEY, Associated Press Writer Bill Poovey, Associated Press Writer Sat Apr 18, 9:58 am ET

CHATTANOOGA , Tenn. – Three patients exposed to contaminated medical equipment at Veterans Affairs hospitals have tested positive for HIV, the agency said Friday.

Initial tests show one patient each from VA medical facilities in Murfreesboro , Tenn. ; Augusta , Ga. ; and Miami has the virus that causes AIDS, according to a VA statement.

The three cases included one positive HIV test reported earlier this month, but the VA didn't identify the facility involved at the time.

The patients are among more than 10,000 getting tested because they were treated with endoscopic equipment that wasn't properly sterilized and exposed them to other people's body fluids.

Vietnam veteran Samuel Mendes, 60, said he was surprised to learn of an HIV case linked to the Miami facility, where he had a colonoscopy. He was told he wasn't among those at risk.

"I was hoping and expecting to not get anyone contaminated like that," he said. "It's probably a little worse than we thought."

The VA also said there have been six positive tests for the hepatitis B virus and 19 positive tests for hepatitis C at the three locations.

There's no way to prove patients were exposed to the viruses at its facilities, the agency said.

"These are not necessarily linked to any endoscopy issues and the evaluation continues," the statement said.

The VA has said it does not yet know if veterans treated with the same kind of equipment at its other 150 hospitals may have been exposed to the same mistake before the department had a nationwide safety training campaign.

An agency spokeswoman has said the mistake with the equipment was corrected nationwide by the time the campaign ended March 14. The problems discovered in December date back more than five years at the Murfreesboro and Miami hospitals.

The VA's disclosure Friday was the department's first comment since April 3, when the VA reported the one positive HIV test.

VA spokeswoman Katie Roberts has declined to provide any details on how widespread the problems might have been other than saying a review of the situation continues.

She said in an e-mail Friday that "there is a very small risk of harm to patients from the procedures at each site." She said the HIV results "still need to be verified" in additional tests.

The VA statement shows the number of "potentially affected" patients totals 10,797, including 6,387 who had colonoscopies at Murfreesboro , 3,341 who had colonoscopies at Miami and 1,069 who were treated at the ear, nose and throat clinic at Augusta .

More than 5,400 patients, about half of those at risk, have been notified of their follow-up test results, the VA said.

The Friday statement said the VA is "continuing to notify individuals whose letters have been returned as undeliverable, and working with homeless coordinators to reach veterans with no known home address."

The statement also said the VA has assigned more than 100 employees at the three locations to "ensure that affected veterans receive prompt testing and appropriate counseling."

All three sites used endoscopic equipment made by Olympus American Inc., which has said in a statement it is helping the VA address problems with "inadvertently neglecting to appropriately reprocess a specific auxiliary water tube."

Charles Rollins, 62, who served three tours in Vietnam with the Navy from 1966 to 1969, said the news concerns him because he's used the Augusta ear, nose and throat clinic several times.

"That's terrible," he said by phone as he socialized at an American Legion post in Augusta .

Singer of the German pop group 'No Angels' prosecuted for pass HIV

File photo of Nadja Benaissa of the German pop group 'No ...Police have arrested Nadja Benaissa a 26-year-old singer in Germany 's most successful girl band, "No Angels", on suspicion of infecting a man with the HIV virus by having unprotected sex, prosecutors said April 14, 2009.

"There is an urgent suspicion that the accused had unprotected sexual intercourse with three people in the years 2004 and 2006 without indicating beforehand that she was HIV positive," said the prosecutors.

Benaissa's lawyers said there was no evidence that their client had acted in a criminal way.

REUTERS/Morris Mac Matzen/Files ( GERMANY ENTERTAINMENT CRIME LAW)

 

 

Poor prisons creating HIV time-bomb: U.N.

Thu Apr 16, 2009 4:57pm EDT

By Sylvia Westall

ThumbnailVIENNA (Reuters) - HIV spread through drug abuse is rampant in overcrowded prisons across the world, posing a health risk to society when infected inmates are released, the head of the U.N. drugs and crimes agency said on Thursday.

If prisons are a reflection of society as a whole "we are seeing a disaster around the world," Antonio Maria Costa said, highlighting substandard prisons as one of the major concerns of the U.N. Office on Drugs and Crime (UNODC).

There are around 30 million people under detention at any given time, the UNODC said, and the spread of HIV through drug abuse in prisons is a severe problem.

Costa warned of a time-bomb when large numbers of infected inmates are released.

"This is a health bomb because of HIV they take along and this is a bomb because prisons are universities for criminals," he told a news conference.

Costa said the problem of overcrowding in jails was especially bad in Africa and Central America , where he had visited some prisons housing up to ten times the number of inmates they were built for.

One prison he visited in Port-au-Prince , Haiti , contained around 4,000 prisoners but had been built for 420. Inmates had to stand because the rooms were so crowded and they had nowhere to sleep. In other countries, prisons house two to three times the number of prisoners they should, Costa said. He said the global economic crisis was already slowing the construction of prisons and that he was not optimistic conditions would improve soon.

"Money for prisons is limited worldwide ... priority is given to children, to education, to health, to the elderly."

The United Nations has led a 54-year campaign to improve prisons, developing a set of standards for how they should be run and how inmates should be treated with guidance on food, shelter and clothing.

Costa said the United Nations needed to encourage countries to follow these guidelines and to look at alternatives to prison for minor crimes to ease overcrowding.

(Editing by Katie Nguyen)


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