News (Updated August 6, 2006)

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AIDS drugs still effective after 10 years

LONDON (Reuters) - Ten years after they were introduced in Europe and North America, HIV/AIDS drugs are still effective but many patients are not being put on them soon enough, scientists said on Friday.

Experts had feared the AIDS virus would become resistant to the treatments and deaths would increase but research published ahead of an international AIDS conference in Toronto later this month has shown it has not happened.

The combinations of drugs reduce mortality and progression to AIDS by about 80-90 percent but tuberculosis (TB) has become a deadly co-infection in patients.

"Ten years on these treatments still work as well as they did initially (but) there is a change in terms of TB becoming more important," said Professor Matthias Egger, of the University of Bern in Switzerland, said in an interview.


     He said people should be diagnosed and start treatment earlier.
     "If that would happen these drugs would even achieve more."

The findings of the Antiretroviral Therapy Cohort Collaboration reported in the Lancet medical journal are based on an analysis of data on more than 22,200 HIV positive people in Europe and North America who started treatment between 1995 and 2003.

More than 40 million people worldwide are living with HIV/AIDS, the majority in sub-Saharan Africa. About 1.3 million people in low- and middle-income countries were receiving AIDS drugs by the end of 2005, according to the World Health Organisation.

Although it varies, Egger, a co-author of the study, said there was widespread consensus that patients should start treatment when their CD4 cell count, a measure of immune system response, dropped below 350 or if the person was unwell or showed symptoms of illness.

The median CD4 cell count when starting treatment increased from 170 in 1995-1996 to 269 in 1998 but then dropped to around 200, according to the research.

People who start treatment with a CD4 count less than 200 have a higher risk of their illness progressing and of dying of AIDS than patients with a higher baseline count, the scientists added in the study.

 

Aging face of HIV poses new challenges

By KAREN MATTHEWS, Associated Press WriterFri Aug 4, 8:35 PM ET

Pat Shelton has had the AIDS virus for at least 15 years, and also struggles with hepatitis C and high blood pressure. But what is bothering her most on this sultry summer day are hot flashes.

"I've gone through hell with my menopause," said Shelton, an elegant woman who recently swapped her dreadlocks for a close-cropped look while trying to stay cool. "It's kicking me. But HIV, I've been very blessed. I don't know why."

The 53-year-old Shelton, whose drug regimen has kept her HIV from developing into full-blown AIDS, in many ways represents the changing face of the HIV population in New York and around the country: They are getting older and presenting new challenges to health-care providers.

In New York City, the epicenter of AIDS in the United States, 30 percent of the 100,000 people with HIV are over 50, and 70 percent are over 40, according to the city health department. Nationwide, 27 percent of people with AIDS are now over 50, the Centers for Disease Control reported.

"Here is a group of people who, yes, they have HIV, but they're going to get other illnesses," said Stephen Karpiak, the associate director of research for the AIDS Community Research Initiative of America (ACRIA). "And we don't know the interaction of all the drugs. There are God knows how many hundreds of drugs used by folks for cardiac issues, osteoporosis, arthritis — we don't know those interactions at all.

"No one's ever looked at them. Someone needs to do trials."

Karpiak's agency conducted a study, released this week, that examined the many challenges faced by people with the AIDS virus.

The AIDS service organizations that arose after the epidemic hit in the 1980s were designed to provide care and counseling to people facing shortened life spans. While there's still no cure for AIDS, antiretroviral drugs have made it a manageable illness for many patients and prolonged their lives beyond what once seemed possible.

As this group ages, they fall prey to a host of conditions that require medicines that may interfere with the effectiveness of AIDS drugs.

And that's if the condition gets diagnosed at all. AIDS patients typically see infectious disease specialists who may not have their antennae out for unrelated diseases, Karpiak said.

They don't look for age-related problems, he said. "That is not their profession."

Conversely, doctors unfamiliar with AIDS may not suspect that older patients have the disease.

Because AIDS arose in the United States among gay men, a stigmatized group, it remains more ostracized than other diseases. Fearing rejection, people with AIDS often isolate themselves. Isolation becomes more of a problem with age, said Karpiak, who noted that 70 percent of the people in the study live alone.

"This is an isolated, stigmatized group of people who have been largely neglected by their churches, by their communities," he said. "Half have not told their families. ... And as you age, you need those people for emotional and everyday support."

Without friends and family, Karpiak said, older people with HIV turn to home health aides. That creates the potential of overburdening the system as the number of HIV positive people over 50 continues to rise.

Marjorie Hill of Gay Men's Health Crisis, one of the nation's largest AIDS service organizations, said 33 percent of the agency's 15,000 clients are over 50 — up from 25 percent two or three years ago.

Among the organization's tailored services are meals and exercise classes better suited for older clients.

In addition, Hill said, a public service campaign featuring older people — unlike the subway and magazine ads that typically show images of handsome young men — is in the works.

"We are actively fund-raising to develop a campaign targeting persons over 50 with prevention and education," she said.

Shelton, a former drug user who tested positive for HIV in 1991, has been an AIDS peer educator since 1998. She is trained to give support but gets support herself at Copacetic Women, a group for women with HIV over 50.

"I really don't feel too comfortable sitting in a group with people my children's age," she said. "They're not really going to open up or listen to what I really have to say. ... We have concerns and health problems that the doctors are not taking care of. We needed a safe haven."

 

CytRx Completes HIV Vaccine Trial

Monday July 31, 9:26 am ET

LOS ANGELES (AP) -- Biopharmaceutical company CytRx Corp. said an early-stage study of a possible HIV vaccine showed positive results.

The study showed the vaccine, based on DNA technology, was effective at producing immune responses to the virus and was well-tolerated. The results will be filed with the Food and Drug Administration in August. The trial began in April 2004 on the compound, DP6-001, developed by researchers at University of Massachusetts Medical School and Advanced Bioscience Laboratories.

The trial looked at the drug candidate's effect on 34 healthy volunteers, divided up into groups receiving doses differently. Each group, whether receiving the vaccine three times a day under the skin or in muscle, experienced positive results.

World health officials estimate 39 million people are infected with HIV, the virus that causes AIDS, and that more than 3 million people are expected to die from AIDS this year.

 

Canada concedes must do more to fight HIV/AIDS

Tue Aug 1, 2006 08:32 AM ET

OTTAWA (Reuters) - Canada said on Monday it needed to do more to fight the spread of the HIV virus and AIDS after new data showed the number of victims infected was growing steadily.

The number of people with HIV/AIDS is now about 58,000 - 0.2 percent of the population - compared with 50,000 in 2002. More than a quarter of sufferers do not know they have been infected, the Public Health Agency of Canada said in a report.

"I wouldn't interpret this data to say the programs (to combat the disease) are not working, but certainly more needs to be done," said the federal agency's Dr Frank Plummer.

"The number of Canadians living with HIV infection will likely continue to increase in years to come as new infection rates continue and survival rates improve," he told reporters on a conference call.

Plummer said money needed to start flowing from a federal fund designed to cut infection rates among the most vulnerable sections of the population. These include aboriginals, who have an infection rate three times higher than other Canadians.

Other groups at risk include women - who represent about 20 per cent of all Canadians infected with HIV - as well as prisoners and people from countries where HIV is endemic.

An estimated 2,300 to 4,500 new HIV infections occurred in 2005 compared with 2,100 to 4,000 in 2002, the last time the health agency compiled such a report. The majority of overall cases, 51 percent, stem from men having sex with men.

"Canada still has a way to go before the threat of HIV/AIDS is eliminated. Groups that have seen a decrease in infection rates are still considered at-risk and progress to date cannot be taken for granted," the health agency said.

Next month Toronto will host a major international conference on AIDS but Prime Minister Stephen Harper - whose Conservatives take a relatively hard line on social issues - will not be present.

Harper, who plans to reopen a debate on whether to scrap laws allowing gay marriage, also skipped the opening of a gay and lesbian games festival in Montreal over the weekend.

Public Works Minister Michael Fortier attended instead and media reports said he was loudly booed when he tried to address the opening ceremony on Saturday.

 

AIDS researcher proposes method to 'extinguish' HIV epidemic

Last Updated Fri, 04 Aug 2006 15:49:32 EDT

CBC News

Expanding free access to drug therapies for everyone infected with HIV could eventually stop the spread of the virus, says a leading Vancouver AIDS researcher.

Dr. Julio Montaner says the HIV/AIDS epidemic could be wiped out in 30 to 40 years.  (CBC file) Dr. Julio Montaner says the HIV/AIDS epidemic could be wiped out in 30 to 40 years. (CBC file)

The hypothesis is based on mounting evidence that transmission of the virus drops significantly when people take anti-retroviral drugs, as the amount of virus circulating in their blood goes down.

If viral loads drop to undetectable levels, it's as if HIV is quarantined and can no longer be transmitted to others.

Dr. Julio Montaner, director of the B.C. Centre for Excellence in HIV/AIDS, proposed the idea in a viewpoint article appearing in Saturday's special issue of medical journal The Lancet devoted to AIDS research.

"This is a mathematical model, if you want to call it that way, that suggests that if we were to aggressively expand the anti-retroviral therapy use, we could see a very substantial decrease in transmissions," Montaner said.

"In fact, over a period of three to four decades, we could see an extinguishing of the HIV epidemic."

The model is theoretical, based on data from Taiwan showing new infections fell 53 per cent after free access to highly active anti-retroviral therapy or HAART was introduced.

Montaner cautioned the idea is a secondary preventive measure, not a licence for careless sexual behaviour.

Testing idea

The simple idea could be cost effective if it reduces the mounting incidence of cases of HIV/AIDS worldwide, Montaner and his co-authors said.

The current approach is not sustainable given the growth of the HIV global pandemic in the face of prevention and treatment strategies that aren't completely effective and the lack of a preventive vaccine, they said.

"We have received a lot of encouraging support from our colleagues not only in North America, but in the rest of the world," said Montaner, who also chairs AIDS research at the University of British Columbia. 

But the idea was dismissed by Dr. Philip Berger, a Toronto physician who has been working in Lesotho, an African nation where an estimated 23 per cent of adults are HIV positive.

People who are infected with HIV may not be willing to start taking antiretroviral drugs before treatment is needed, given its side effects, Berger said.

In sub-Saharan Africa where people are dying because of lack of treatment, the priority should be on meeting emergency needs now, he said.

Montaner now hopes to test the hypothesis with his own study in B.C.

 

 


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