News (Updated January 9, 2006)

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Herpes in pregnancy may raise HIV risk for baby

Wed Dec 28, 2005 10:16 PM ET

By Anne Harding

NEW YORK (Reuters Health) - HIV-positive women diagnosed with genital herpes during pregnancy appear to be quite likely to pass HIV to their infants, according to a study conducted in New York City.

Other studies are needed to confirm the relationship, lead investigator Dr. Katherine T. Chen of Columbia University told Reuters Health.

At present, she noted, HIV-positive women who contract herpes during pregnancy are treated for herpes infection and given medications beginning at approximately 36 weeks to prevent the transmission of herpes to the infant -- the same way such infections are treated in pregnant women without HIV.

The big question that remains unanswered, Chen explained, is whether HIV-positive women with any prior or current history of herpes infection should receive anti-herpes drugs throughout pregnancy in order to prevent transmission not only of herpes but also HIV.

As reported in the journal Obstetrics and Gynecology, Chen and her team evaluated 402 HIV-positive pregnant women, 5 percent of whom had a diagnosis of herpes during pregnancy. Six of the 21 women with herpes delivered HIV-infected infants.

After accounting for other risk factors for perinatal HIV transmission, the researchers found that herpes infection raised the risk of the baby becoming infected with HIV by nearly fivefold.

One of the study's strengths is that herpes diagnosis was clinically confirmed; its weaknesses include the lack of information on HIV levels for the pregnant women, Chen told Reuters Health. She and her colleagues are currently conducting a trial in which they are analyzing viral levels for both HIV and herpes in the genital fluid of HIV-positive pregnant women.

SOURCE: Obstetrics and Gynecology, December 2005.

 

Indian biotech firms cash in on promise of better tomorrow

Tue Jan 3,10:08 AM ET

PhotoCashing in on a high birth rate and the enormous potential of stem cell research, India's biotechnology firms are coaxing more parents to bank blood from their newborn's umbilical cord.

Bondita Bhattacharya, 39, who is married to a software engineer, is among more than 4,000 Indian parents who have had the blood cells from their children frozen, to be revived if and when there is a scientific breakthrough.

Bhattacharya, whose baby was born last month, said she had paid 60,000 rupees (1,333 dollars) for the process as she had "nothing to lose".

"It is like taking an insurance policy. It is safe," she told AFP. "In the future I am sure there will be a breakthrough in stem cell research. They (scientists) may come out with a cure for diabetes or cancer. I will regret if I am not able to take advantage of that."

Stem cells are master cells from which the body's immune and blood system originate and which can develop into cells of any organ.

Blood which is extracted from the baby's umbilical cord and placenta discarded after birth are loaded with stem cells, according to doctor Nalini Krishnan, medical advisor of LifeCell, a firm which deals in preserving cord blood.

These cells can help cure more than 75 serious ailments, she says.

"Collecting and preserving the baby's cord blood stem cells is a security blanket for your baby and immediate family members. It is effective in the treatment of leukemia, anaemia, inherited disorders and several other deficiencies of the immune system," Krishnan says.

"Lifestyle diseases such as diabetes, liver disorders and heart ailments can also be treated with stem cells," she adds.

The two Indian companies which offer cord blood cell banking --- LifeCell and Reliance Life Sciences -- have a combined repository of more than 4,000 units, with Reliance dominating with 3,000 units.

"Our target is to get to 15,000 units by the end of next year and grow our presence from the current six cities to 25," says Abhay Kumar, chief executive of LifeCell, which has a collaboration with Cyro-Cell International of the United States.

"We will be opening two banking centres outside India during the next year and (expect to) clock 10 billion rupees (222 million dollars) within the next five years," Kumar tells AFP. LifeCell was set up a year ago. "The opportunity is big as there are 26 million births in India every year."

Prasad Mangipudi, marketing vice-president of LifeCell says the company followed "ethical standards" despite controversies surrounding the stem cell research.

In December, South Korean investigators said that the apparent landmark stem cell research by cloning expert Hwang Woo-Suk had been faked, turning the one-time national hero into a disgraced fabricator.

Roopa Devi, 26, a doctor, who banked her son's cord blood cells at LifeCell's facility in southern city of Chennai a month ago, is not worried by the controversy.

Banking blood, she says, is the "best gift" a parent can give to their children.

"In today's world everybody needs a little bit of help to sail through life. Why should my son be denied that?" asks Devi. "I do not want to shut any options for my son. I know at present the research is shrouded in a bit of controversy. But you never know what will happen in the future."

Doctors harvest the cells once the umbilical cord is clamped and cut, using a 'collection kit' supplied by one of the two companies. The blood is then packaged in a special shipping material provided in the kit.

Company officials then ship the package to their laboratory, where the stem cells are processed and tested for infectious diseases such as hepatitis, HIV and malaria.

After that it is frozen in liquid nitrogen at minus 196 degree Centigrade (minus 320 degree Fahrenheit) at a facility which official Kumar says is "earthquake- and bomb-proof".

K.V. Subramaniam, chief executive of Reliance Life Sciences, says research using cord blood cells was easier than from embryonic stem cells -- derived from human embryos -- or from adult bone marrow due to easier availability.

"Research has proven beyond doubt the usefulness of cord blood stem cells as an alternative to traditional bone marrow transplantation. As research gets deeper it is expected to yield many more benefits to the donors who decide to bank cord blood stem cells," he said.

"India is yet to carry out its first cord blood stem cell transplantation but is getting gearing up for (it). Quite a few countries are betting big on stem cell based therapies," says Subramaniam, who heads a team of 50 stem cell scientists.

Doctor Satish Totey, director of Stem Cell Research at Bangalore's private Manipal Hospital, however, says it is a challenge to extract enough blood cells from the samples brought in as many are already infected.

"Of the 60 or 150 milliliters (2.1 or 5.2 fluid ounces) of blood you bring to the lab you make be able to extract some 15 percent cells. (Will that be) enough in the future is the question?" he asks.


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